(R)-PD 0325901CL
Cat. No.：YN350293
| 产品名称: | (R)-PD 0325901CL |
| CAS No.: | 212631-61-3 |
| Chemical Name: | N-(cyclopropylmethoxy)-3,4,5-trifluoro-2-[(4-iodo-2-methylphenyl)amino]-benzamide |
| Synonyms: | PD-198306; PD 198306; PD198306. |
| 分子量: | 476.2 |
| 分子式: | C18H16F3IN2O2 |
| SMILES: | CC1=CC(I)=CC=C1NC2=C(F)C(F)=C(F)C=C2C(NOCC3CC3)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PD 198306 是一种选择性 MAPK/ERK 激酶 (MEK) 抑制剂。PD 198306 显著降低 Streptozocin 诱导的 ERK1/2 水平升高。具有抗痛觉过敏作用。 |
| IC50和靶点: | |
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Pelletier, J.P., Fernandes, J.C., Brunet, J., et al.In vivo selective inhibition of mitogen-activated protein kinase kinase 1/2 in rabbit experimental osteoarthritis is associated with a reduction in the development of structural changesArthritis Rheum.48(6),1582-1593(2003)
Ripple, M.O., Kim, N., and Springett, R.Acute mitochondrial inhibition by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) 1/2 inhibitors regulates proliferationJ. Biol. Chem.288(5),2933-2940(2013)
Ciruela, A., Dixon, A.K., Bramwell, S., et al.Identification of MEK1 as a novel target for the treatment of neuropathic painBr. J. Pharmacol.138(5),751-756(2003)
