PD184161
Cat. No.：YN350294
CAS No. ：212631-67-9
| 产品名称: | PD184161 |
| CAS No.: | 212631-67-9 |
| Chemical Name: | 5-bromo-2-[(2-chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluoro-benzamide |
| Synonyms: | PD184161;PD-184161 |
| 分子量: | 557.6 |
| 分子式: | C17H13BrClF2IN2O2 |
| SMILES: | FC1=C(NC2=C(Cl)C=C(I)C=C2)C(C(NOCC3CC3)=O)=CC(Br)=C1F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PD184161 是一种口服有效、时间和浓度依赖的MEK抑制剂 (IC50=10-100 nM)。PD184161 抑制细胞增殖并诱导细胞凋亡 (apoptosis)。PD184161 诱导抑郁样行为。 |
| IC50和靶点: | [{name:"MEK:10-100 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Cowan, K.J., and Storey, K.B.Mitogen-activated protein kinases: New signaling pathways functioning in cellular responses to environmental stressJ. Exp. Biol.206(Pt 7),1107-1115(2003)
Dhillon, A.S., Hagan, S., Rath, S., et al.MAP kinase signalling pathways in cancerOncogene26,3279-3290(2007)
VanScyoc, W.S., Holdgate, G.A., Sullivan, J.E., et al.Enzyme kinetics and binding studies on inhibitors of MEK protein kinaseBiochemistry47,5017-5027(2008)
Klein, P.J., Schmidt, C.M., Wiesenauer, C.A., et al.The effects of a novel MEK inhibitor PD184161 on MEK-ERK signaling and growth in human liver cancerNeoplasia8(1),1-8(2006)
