YW1128
Cat. No.：YN450170
| 产品名称: | YW1128 |
| CAS No.: | 2131223-64-6 |
| Chemical Name: | 5-methyl-1-(2-methylphenyl)-N-2-quinolinyl-1H-1,2,3-triazole-4-carboxamide |
| Synonyms: | 5-methyl-1-(2-methylphenyl)-N-2-quinolinyl-1H-1,2,3-triazole-4-carboxamide |
| 分子量: | 343.38208 |
| 分子式: | C20H17N5O |
| SMILES: | O=C(C1=C(C)N(C2=C(C)C=CC=C2)N=N1)NC3=CC=C(C=CC=C4)C4=N3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | YW1128 (compound 3a) 是一种有效的Wnt/β-Catenin抑制剂。 YW1128 诱导β-catenin的蛋白酶体降解，随后抑制细胞中的 Wnt/β-catenin 信号传导。YW1128 显着降低肝脏脂质积累。YW1128 提高了喂食高脂肪饮食的小鼠的葡萄糖耐量，而没有明显的毒性。YW1128 下调参与葡萄糖 (PEPCK，G6PASE) 和脂肪酸合成代谢 (FASN, ACAA1A, ACOT4, SCD1) 的基因。 |
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Obianom, O.N., Ai, Y., Li, Y., et al.Triazole-based inhibitors of the Wnt/β-catenin signaling pathway improve glucose and lipid metabolism in diet-induced obese miceJ. Med. Chem.62(2),727-741(2019)
