HPK1-IN-7
Cat. No.：YN350297
CAS No. ：2320462-65-3
| 产品名称: | HPK1-IN-7 |
| CAS No.: | 2320462-65-3 |
| Chemical Name: | |
| Synonyms: | compound K |
| 分子量: | 458.47 |
| 分子式: | C24H22N6O4 |
| SMILES: | 暂无 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | HPK1-IN-7 是一种有效的口服活性HPK1(造血祖细胞激酶1, MAP4K1) 抑制剂(IC50=2.6 nM)，具有优良的家族和激酶组选择性。HPK1-IN-7 对IRAK4(59 nM) 和 GLK (140 nM) 具有选择性。HPK1-IN-7 联合抗 PD1 对 MC38 同基因肿瘤模型显示出强大的疗效。 |
| IC50和靶点: | [{name:"HPK1:2.6 nM (IC50)"},{name: "GLK/MAP4K3:140 nM (IC50)"},{name: "IRAK4:59 nM (IC50)"},{name: "Fms/CSFR:3.2 nM (IC50)"},{name: "FLT3:25.4 nM (IC50)"},{name: "AMPKA1:44.3 nM (IC50)"},{name: "cKIT:45.7 nM (IC50)"},{name: "MST1:55.1 nM (IC50)"},{name: "ICK:65.1 nM (IC50)"},{name: "MST2:78.5 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
