GNE-9815
Cat. No.：YN350300
CAS No. ：2729996-45-4
| 产品名称: | GNE-9815 |
| CAS No.: | 2729996-45-4 |
| Chemical Name: | |
| Synonyms: | GNE9815;GNE-9815 |
| 分子量: | 455.48 |
| 分子式: | C26H22FN5O2 |
| SMILES: | CN1N=CC2=CC(=CN=C2C1=O)C3=CC(=C(F)C=C3C)NC(=O)C4=CC(=CC=C4)C(C)(C)C#N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GNE-9815 (化合物 7) 是一种高选择性的、具有较好口服生物利用度的泛型RAF抑制剂，其对CRAF和BRAF的Ki值分别为 0.062 和 0.19 nM。GNE-9815 联合MEK抑制剂Cobimetinib(HY-13064) 显示出协同调节MAPK途径的作用。GNE-9815 可用于KRAS突变型癌症的研究。 |
| IC50和靶点: | [{name:"CRAF:0.062 nM (Ki)"},{name: "Braf:0.19 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
