EO 1428
Cat. No.：YN350301
| 产品名称: | EO 1428 |
| CAS No.: | 321351-00-2 |
| Chemical Name: | [4-[(2-amino-4-bromophenyl)amino]-2-chlorophenyl](2-methylphenyl)-methanone |
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| 分子量: | 415.7 |
| 分子式: | C20H16BrClN2O |
| SMILES: | BrC1=CC(N)=C(NC2=CC=C(C(C3=CC=CC=C3C)=O)C(Cl)=C2)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | EO 1428 是一种高度特异性的氨基二苯甲酮类p38抑制剂。EO 1428 (1 μM) 显著减弱 LPS 诱导的肿瘤坏死因子 α 转换酶 (TACE) 活性上调。 |
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Ottosen, E.R., Sørensen, M.D., Björkling, F., et al.Synthesis and structure-activity relationship of aminobenzophenones. A novel class of p38 MAP kinase inhibitors with high antiinflammatory activityJ. Med. Chem.46(26),5651-5662(2003)
