SANT 2
Cat. No.：YN450177
| 产品名称: | SANT 2 |
| CAS No.: | 329196-48-7 |
| Chemical Name: | N-[3-(1H-benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxy-benzamide |
| Synonyms: | |
| 分子量: | 480 |
| 分子式: | C26H26ClN3O4 |
| SMILES: | CCOC1=C(OCC)C(OCC)=CC(C(NC2=CC=C(Cl)C(C3=NC(C=CC=C4)=C4N3)=C2)=O)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SANT 2 是 Hh 信号通路的有效拮抗剂。Hedgehog(Hh) 信号传导在胚胎发育和成人组织稳态的细胞信号传导中起重要作用。SANT 2 具有研究多种恶性肿瘤的潜力，包括 Gorlin 综合征 (一种易患基底细胞癌、髓母细胞瘤和横纹肌肉瘤的疾病)、前列腺癌、胰腺癌和乳腺癌。 |
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Chen, J.K., Taipale, J., Young, K.E., et al.Small molecule modulation of smoothened activityProc. Natl. Acad. Sci. USA99(22),14071-14076(2002)
Rominger, C.M., Bee, W.L.T., Copeland, R.A., et al.Evidence for allosteric interactions of antagonist binding to the smoothened receptorJ. Pharmacol. Exp. Ther.329(3),995-1005(2009)
