MRT-10
Cat. No.：YN450178
CAS No. ：330829-30-6
| 产品名称: | MRT-10 |
| CAS No.: | 330829-30-6 |
| Chemical Name: | N-[[[3-(benzoylamino)phenyl]amino]thioxomethyl]-3,4,5-trimethoxy-benzamide |
| Synonyms: | |
| 分子量: | 465.5 |
| 分子式: | C24H23N3O5S |
| SMILES: | O=C(NC1=CC=CC(NC(NC(C2=CC(OC)=C(OC)C(OC)=C2)=O)=S)=C1)C3=CC=CC=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MRT-10 是一种七跨膜平滑受体 (Smo) 拮抗剂，在各种Hedgehog(Hh) 测定中，IC50为 0.65 μM。MRT-10 在 Bodipycyclopamine 结合位点水平与Smo受体结合。MRT-10可用于癌症研究。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Manetti, F., Faure, H., Roudaut, H., et al.Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonistsMol. Pharm.78(4),658-665(2010)
Solinas, A., Faure, H., Roudaut, H., et al.Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activityJ. Med. Chem.55(4),1559-1571(2012)
