SM-7368
Cat. No.：YN350303
CAS No. ：380623-76-7
| 产品名称: | SM-7368 |
| CAS No.: | 380623-76-7 |
| Chemical Name: | 3-chloro-4-nitro-N-(5-nitro-2-thiazolyl)-benzamide |
| Synonyms: | |
| 分子量: | 328.7 |
| 分子式: | C10H5ClN4O5S |
| SMILES: | ClC1=C([N+]([O-])=O)C=CC(C(NC2=NC=C([N+]([O-])=O)S2)=O)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SM-7368 是一种NF-kB抑制剂，靶向抑制下游的MAPK p38。SM-7368 还抑制 TNF-α 诱导的MMP-9上调。SM-7368 可用于靶向 TNF-α 介导的肿瘤侵袭和转移的化疗研究。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Lee, H.Y., Park, K.S., Kim, M.K., et al.A small compound that inhibits tumor necrosis factor-α-induced matrix metalloproteinase-9 upregulationBiochem. Biophys. Res. Commun.336(2),716-722(2005)
Matsumoto, J., Dohgu, S., Takata, F., et al.TNF-α-sensitive brain pericytes activate microglia by releasing IL-6 through cooperation between IκB-NFκB and JAK-STAT3 pathwaysBrain Res.1692,34-44(2018)
Kuntz, S., Kunz, C., and Rudloff, S.Carbonyl compounds methylglyoxal and glyoxal affect interleukin-8 secretion in intestinal cells by superoxide anion generation and activation of MAPK p38Mol. Nutr. Food Res.54(10),1458-1467(2010)
