BMS-582949
Cat. No.：YN350307
| 产品名称: | BMS-582949 |
| CAS No.: | 623152-17-0 |
| Chemical Name: | 4-[[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-propyl-pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide |
| Synonyms: | BMS 582949;4-[5-(cyclopropylcarbamoyl)-2-methylanilino]-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide;38P;3mvl;UNII-CR743OME9E |
| 分子量: | 406.5 |
| 分子式: | C22H26N6O2 |
| SMILES: | CC1=CC=C(C(NC2CC2)=O)C=C1NC3=NC=NN4C3=C(C)C(C(NCCC)=O)=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BMS-582949 (compound 7k) 是一种口服有效的、高度选择性的p38αMAP酶抑制剂，对p38α的IC50为 13 nM，对 TNFα 的IC50为 50 nM。BMS-582949 可用于研究类风湿性关节炎。 |
| IC50和靶点: | [{name:"p38α:13 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Liu, C., Lin, J., Wrobleski, S.T., et al.Discovery of 4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl-N-propylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide (BMS-582949), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseasesJ. Med. Chem.53(18),6629-6639(2010)
