MK2-IN-3
Cat. No.：YN350309
CAS No. ：724711-21-1
| 产品名称: | MK2-IN-3 |
| CAS No.: | 724711-21-1 |
| Chemical Name: | 1,5,6,7-Tetrahydro-2-[2-(3-quinolinyl)-4-pyridinyl]-4H-pyrrolo[3,2-c]pyridin-4-one |
| Synonyms: | MK2-IN-3 |
| 分子量: | 340.38 |
| 分子式: | C21H16N4O |
| SMILES: | O=C1NCCC2=C1C=C([NH]2)C3=CC(=NC=C3)C4=CC5=CC=CC=C5N=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MK2-IN-3 是一种有效和选择性的MAPKAP-K2 (MK-2)抑制剂，IC50值为 8.5 nM。MK2-IN-3 对 MK-3，MK-5，ERK2，MNK1，p38a (IC50=0.21, 0.081, 3.44, 5.7, >100 μM) 和 MSK1，MSK2，CDK2，JNK2，IKK2 (IC50>200 μM) 表现出良好的选择性。MK2-IN-3 可以减少 U937 细胞和体内 TNFα 的产生。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Anderson, D.R., et al.: J. Med. Chem., 50, 2647 (2007)
