CC-401
Cat. No.：YN350319
| 产品名称: | CC-401 |
| CAS No.: | 395104-30-0 |
| Chemical Name: | 3-[3-[2-(1-piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole |
| Synonyms: | |
| 分子量: | 388.5 |
| 分子式: | C22H24N6O |
| SMILES: | C1(C2=NN=CN2)=CC=C3C(C(C4=CC=CC(OCCN5CCCCC5)=C4)=NN3)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CC-401是第二代ATP竞争性JNK抑制剂，具有抗肿瘤活性。 |
| IC50和靶点: | [{name:"JNK:25-50 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
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Uehara, T., Xi Peng, X., Bennett, B., et al.c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantationTransplantation78(3),324-332(2004)
Ma, F.Y., Flanc, R.S., Tesch, G.H., et al.A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosisJ. Am. Soc. Nephrol.18(2),472-484(2007)
Kanellis, J., Ma, F.Y., Kandane-Rathnayake, R., et al.JNK signalling in human and experimental renal ischaemia/reperfusion injuryNephrol. Dial. Transplant25(9),2898-2908(2010)
