PT-262
Cat. No.：YN350322
CAS No. ：86811-36-1
| 产品名称: | PT-262 |
| CAS No.: | 86811-36-1 |
| Chemical Name: | |
| Synonyms: | |
| 分子量: | 276.72 |
| 分子式: | C14H13ClN2O2 |
| SMILES: | O=C(C(N1CCCCC1)=C2Cl)C3=C(N=CC=C3)C2=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PT-262 是一种有效的ROCK抑制剂，IC50值约为 5 μM。PT-262 诱导线粒体膜电位的丧失并提高 caspase-3 的激活和细胞凋亡。PT-262 通过 p53 独立途径抑制ERK和CDC2磷酸化。PT-262 阻断细胞骨架功能和细胞迁移。PT-262 具有抗癌活性。 |
| IC50和靶点: | [{name:"ROCK:5 μM (IC50)'}, 'ERK', 'CDK2'] |
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| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
