Bisindolylmaleimide V
Cat. No.：YN350327
| 产品名称: | Bisindolylmaleimide V |
| CAS No.: | 113963-68-1 |
| Chemical Name: | 3,4-di-1H-indol-3-yl-1-methyl-1H-pyrrole-2,5-dione |
| Synonyms: | BIM V |
| 分子量: | 341.4 |
| 分子式: | C21H15N3O2 |
| SMILES: | O=C1C(=C(c2c[nH]c3ccccc23)C(=O)N1C)c1c[nH]c2ccccc12 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bisindolylmaleimide V 是一种可穿透细胞膜的用于抑制蛋白激酶 C 相关研究的阴性对照品，其IC50值超过 100 µM。Bisindolylmaleimide V 在体内阻断有丝分裂原刺激的蛋白激酶 p70s6k/p85s6k(S6K) 的激活，其IC50为 8 µM。 |
| IC50和靶点: | |
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Lazareno, S., Popham, A., and Birdsall, N.J.M.Muscarinic interactions of bisindolylmaleimide analoguesEur. J. Pharmacol.360(2-3),281-284(1998)
Toullec, D., Pianetti, P., Coste, H., et al.The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase CJ. Biol. Chem.266(24),15771-15781(1991)
Davis, P.D., Hill, C.H., Lawton, G., et al.Inhibitors of protein kinase C. 1.1 2,3-bisarylmaleimidesJ. Med. Chem.35(1),177-184(1992)
Marmy-Conus, N., Hannan, K.M., and Pearson, R.B.Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70s6k/p85s6k: Implications for the analysis of S6K signallingFEBS Lett.519(1-3),135-140(2002)
