ABC99
Cat. No.：YN450205
| 产品名称: | ABC99 |
| CAS No.: | 2331255-53-7 |
| Chemical Name: | 7-(4-chlorobenzyl)-1,3-dioxohexahydroimidazo[1,5-a]pyrazin-2(3H)-yl-2,3-dihydro-4H-benzo[b][1,4]oxazine-4-carboxylate |
| Synonyms: | |
| 分子量: | 456.8788 |
| 分子式: | C22H21ClN4O5 |
| SMILES: | ClC1=CC=C(CN2CC(C(N(OC(N3C(C=CC=C4)=C4OCC3)=O)C5=O)=O)N5CC2)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BC99 是一种 N-hydroxyhydantoin (NHH) carbamate，选择性抑制 Wnt-deacylating 酶NOTUM(IC50=13 nM)。BC99 在NOTUM存在的情况下保留 Wnt3A 信号。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Suciu, R.M., Cognetta, A.B., III., Potter, Z.E., et al.Selective irreversible inhibitors of the Wnt-deacylating enzyme NOTUM developed by activity-based protein profilingACS Med. Chem. Lett.9(6),563-568(2018)
