(E/Z)-Necrosulfonamide
Cat. No.：YN350352
| 产品名称: | (E/Z)-Necrosulfonamide |
| CAS No.: | 432531-71-0 |
| Chemical Name: | N-[4-[[(3-Methoxypyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide; (E)-N-[4-[N-(3-methoxypyrazin-2-yl)sulfamoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylamide; |
| Synonyms: | MLKL药理抑制剂(NECROSULFONAMIDE |
| 分子量: | 461.47 |
| 分子式: | C18H15N5O6S2 |
| SMILES: | 暂无 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (E/Z)-Necrosulfonamide 是Necrosulfonamide(HY-100573) 的消旋体。Necrosulfonamide，一种necroptosis抑制剂，通过选择性靶向(MLKL)。Necrosulfonamide 阻止 MLKL-RIP1-RIP3 坏死小体复合体与其下游效应子相互作用。MLKL 是诱导坏死过程中 RIP3 的重要底物。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Sun, L. et al.: Cell, 148, 213 (2012)
