Triparanol
Cat. No.：YN450224
| 产品名称: | Triparanol |
| CAS No.: | 78-41-1 |
| Chemical Name: | 4-chloro-α-[4-[2-(diethylamino)ethoxy]phenyl]-α-(4-methylphenyl)-benzeneethanol |
| Synonyms: | MER-29 |
| 分子量: | 438 |
| 分子式: | C27H32ClNO2 |
| SMILES: | CC1=CC=C(C(CC2=CC=C(Cl)C=C2)(O)C3=CC=C(OCCN(CC)CC)C=C3)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Triparanol (MER-29) 是一种有效的胆固醇生物合成 (cholesterolbiosynthesis) 抑制剂，可阻断 24-脱氢胆固醇还原酶(24-DHCR)。Triparanol 可以干扰Hedgehog信号分子的翻译后修饰及其受体 PTCH1 的甾醇传感结构域，导致 Hh 信号的下调。Triparanol 抑制人类肿瘤生长。 |
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Avigan, J., Steinberg, D., Vroman, H.E., et al.Studies of cholesterol biosynthesis. I. The identification of desmosterol in serum and tissues of animals and man treated with MER-29J. Biol. Chem.235(11),3123-3126(1960)
Bae, S.-H., and Paik, Y.-K.Cholesterol biosynthesis from lanosterol: Development of a novel assay method and characterization of rat liver microsomal lanosterol D24-reductaseBiochem. J.326,609-616(1997)
Bi, X., Han, X., Zhang, F., et al.Triparanol suppresses human tumor growth in vitro and in vivoBiochem. Biophys. Res. Commun.425(3),613-618(2012)
Endo, A.A historical perspective on the discovery of statinsProc. Jpn. Acad. Ser. B. Phys. Biol. Sci.86(5),484-493(2010)
Laughlin, R.C., and Carey, T.F.Cataracts in patients treated with triparanolJAMA181(4),339-340(1962)
