BAY-678
Cat. No.：YN370512
CAS No. ：675103-36-3
| 产品名称: | BAY-678 |
| CAS No.: | 675103-36-3 |
| Chemical Name: | 5-[(4R)-5-acetyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4-pyrimidinyl]-2-pyridinecarbonitrile |
| Synonyms: | |
| 分子量: | 400.35 |
| 分子式: | C₂₀H₁₅F₃N₄O₂ |
| SMILES: | N#CC1=NC=C([C@H](C(C(C)=O)=C(C)N2C3=CC=CC(C(F)(F)F)=C3)NC2=O)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BAY-678 是具有口服生物活性的、高效的、选择性的、人中性粒细胞弹性蛋白酶(HNE)的细胞渗透性抑制剂，其IC50值为 20 nM。BAY-678 也是被基因结构组学联盟 (SGC) 推荐的化学探针。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
von Nussbaum, F., and Li, V.M.J.Neutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases: Into clinical testing with pre-adaptive pharmacophoresBioorg. Med. Chem. Lett.25(20),4370-4381(2015)
von Nussbaum, F., Li, V.M.-J., Allerheiligen, S., et al.Freezing the bioactive conformation to boost potency: The identification of BAY 85-8501, a selective and potent inhibitor of human neutrophil elastase for pulmonary diseasesChemMedChem10(7),1163-1173(2015)
