Alvelestat
Cat. No.：YN372322
CAS No. ：848141-11-7
| 产品名称: | Alvelestat |
| CAS No.: | 848141-11-7 |
| Chemical Name: | 1,2-dihydro-6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-[[5-(methylsulfonyl)-2-pyridinyl]methyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]-3-pyridinecarboxamide |
| Synonyms: | AZD9668 |
| 分子量: | 545.53 |
| 分子式: | C₂₅H₂₂F₃N₅O₄S |
| SMILES: | O=C(C1=CC(C2=CC=NN2C)=C(C)N(C3=CC=CC(C(F)(F)F)=C3)C1=O)NCC4=NC=C(S(=O)(C)=O)C=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Alvelestat (AZD9668) 是一种口服生物利用度，亲和性和选择性的中性粒细胞弹性蛋白酶 (NE) 抑制剂，其pIC50值为 7.9 nM，Ki值为 9.4 nM，Kd值为 9.5 nM。 |
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Stevens, T., Ekholm, K., Gränse, M., et al.AZD9668: Pharmacological characterization of a novel oral inhibitor of neutrophil elastaseJ. Pharmacol. Exp. Ther.339(1),313-320(2011)
