Freselestat
Cat. No.：YN372323
| 产品名称: | Freselestat |
| CAS No.: | 208848-19-5 |
| Chemical Name: | 5-Amino-N-[1-[[5-(1,1-dimethylethyl)-1,3,4-oxadiazol-2-yl]carbonyl]-2-methylpropyl]-6-oxo-2-phenyl-1(6H)-pyrimidineacetamide; ONO 6818; ONO-PO 736 |
| Synonyms: | ONO-6818; ONO-PO-736 |
| 分子量: | 452.51 |
| 分子式: | C₂₃H₂₈N₆O₄ |
| SMILES: | O=C(NC(C(C1=NN=C(C(C)(C)C)O1)=O)C(C)C)CN(C(C2=CC=CC=C2)=NC=C3N)C3=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Freselestat (ONO-6818) 是一种有效且具有口服活性的嗜中性粒细胞弹性蛋白酶 (neutrophil elastase) 抑制剂，Ki为 12.2 nM。Freselestat 对其他蛋白酶（例如胰蛋白酶，蛋白酶3，胰弹性蛋白酶，纤溶酶，凝血酶，胶原酶，组织蛋白酶G和鼠巨噬细胞弹性蛋白酶）的活性低 100 倍以上，并具有有效的抗炎活性。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Ohbayashi, H.: IDrugs, 5, 910 (2002)
Trifilieff, A.: Curr. Opin. Invest. Dr., 3, 1161 (2002)
Ohmoto, K., et al.: Synlett, no vol., 299 (2001)
Ohmoto, K., et al.: J. Med. Chem., 43, 4927 (2000)
