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GW311616 hydrochloride

Cat. No.:YN372362

  • CAS No. :197890-44-1

    • 产品资料
    • 生物活性
    • 参考文献
    • 产品名称: GW311616 hydrochloride
      CAS No.: 197890-44-1
      Chemical Name: (3S,3aS,6aR)-hexahydro-3-(1-methylethyl)-1-(methylsulfonyl)-4-[(2E)-1-oxo-4-(1-piperidinyl)-2-buten-1-yl]-pyrrolo[3,2-b]pyrrol-2(1H)-one, monohydrochloride
      Synonyms:GW311616A
      分子量:433.99
      分子式:C₁₉H₃₂ClN₃O₄S
      SMILES:O=C1[C@@H](C(C)C)[C@@](N(C(/C=C/CN2CCCCC2)=O)CC3)([H])[C@]3([H])N1S(=O)(C)=O.[H]Cl
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: GW-311616 是高活性,口服生物相容性,长效的人中性白细胞弹性蛋白酶 (HNE) 抑制剂,IC50为 22 nM,Ki为 0.31 nM。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Benedek, B., Kopp, B., and Melzig, M.F.Achillea millefolium L. s.l. – is the anti-inflammatory activity mediated by protease inhibition?J. Ethnopharmacol.113(2),312-317(2007)

      Nakabo, S., Ohmura, K., Akizuki, S., et al.Activated neutrophil carbamylates albumin via the release of myeloperoxidase and reactive oxygen species regardless of NETosisMod. Rheumatol.30(2),345-349(2019)

      Macdonald, S.J.F., Dowle, M.D., Harrison, L.A., et al.The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase–GW311616A a development candidateBioorg. Med. Chem. Lett.11(7),895-898(2001)

      Uchida, Y., Freitas, M.C., Zhao, D., et al.The inhibition of neutrophil elastase ameliorates mouse liver damage due to ischemia and reperfusionLiver Transpl.15(8),939-947(2009)

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