Sivelestat sodium
Cat. No.：YN372439
| 产品名称: | Sivelestat sodium |
| CAS No.: | 150374-95-1 |
| Chemical Name: | N-[2-[[[4-(2,2-Dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-glycine Monosodium Salt; ONO 5046-Na; Sodium Sivelestat; |
| Synonyms: | 西维来司钠; ONO5046-Na; Sodium sivelestat; EI546 sodium; LY544349 sodium |
| 分子量: | 456.44 |
| 分子式: | C₂₀H₂₁N₂NaO₇S |
| SMILES: | CC(C)(C)C(OC1=CC=C(S(=O)(NC2=CC=CC=C2C(NCC(O[Na])=O)=O)=O)C=C1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sivelestat (EI546) sodium 是竞争性的人类中性粒细胞弹性蛋白酶的抑制剂，其IC50值为 44 nM，Ki值为 200 nM。Sivelestat (EI546) sodium 有潜力用于COVID-19 的急性肺损伤/急性呼吸窘迫综合征或弥散性血管内凝血的研究。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Sercundes, M. K., et al.: Plos Pathog., 12, 1006054/1-1006054/24 (2016)
Mikumo, H., et al.: Biochem. Biophys. Res. Commun., 486, 205-209 (2017)
