Sivelestat sodium tetrahydrate
Cat. No.：YN372440
CAS No. ：201677-61-4
| 产品名称: | Sivelestat sodium tetrahydrate |
| CAS No.: | 201677-61-4 |
| Chemical Name: | 2,2-dimethyl-propanoic acid, 4-[[[2-[[(carboxymethyl)amino]carbonyl]phenyl]amino]sulfonyl]phenyl ester, monosodium salt, tetrahydrate |
| Synonyms: | 西维来司钠四水合物; EI546 sodium tetrahydrate; LY544349 sodium tetrahydrate; ONO5046 sodium tetrahydrate |
| 分子量: | 528.51 |
| 分子式: | C₂₀H₂₉N₂NaO₁₁S |
| SMILES: | CC(C)(C)C(OC1=CC=C(S(=O)(NC2=CC=CC=C2C(NCC(O[Na])=O)=O)=O)C=C1)=O.O.O.O.O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sivelestat (EI546) sodium tetrahydrate 是竞争性的人类中性粒细胞弹性蛋白酶的抑制剂，其IC50值为 44 nM，Ki值为 200 nM。Sivelestat (EI546) sodium tetrahydrate 有潜力用于COVID-19的急性肺损伤/急性呼吸窘迫综合征或弥散性血管内凝血的研究。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Basse, L.H., Groen, D., and Bouwstra, J.A.Permeability and lipid organization of a novel psoriasis stratum corneum substituteInt. J. Pharm.457(1),275-282(2013)
Martinod, K., Witsch, T., Farley, K., et al.Neutrophil elastase-deficient mice form neutrophil extracellular traps in an experimental model of deep vein thrombosisJ. Thromb. Haemost.14(3),551-558(2016)
Yuan, Q., Jiang, Y.-W., and Fang, Q.-H.Improving effect of Sivelestat on lipopolysaccharide-induced lung injury in ratsAPMIS122(9),810-817(2014)
