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Hypotaurine

Cat. No.:YN370103

  • CAS No. :300-84-5

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    • 生物活性
    • 参考文献
    • 产品名称: Hypotaurine
      CAS No.: 300-84-5
      Chemical Name: 2-amino-ethanesulfinic acid
      Synonyms:亚牛磺酸; 2-Aminoethanesulfinic acid
      分子量:109.15
      分子式:C₂H₇NO₂S
      SMILES:NCCS(O)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Hypotaurine (2-aminoethanesulfinic acid) 是星形胶质细胞中半胱氨酸的牛磺酸生物合成中间体,是甘氨酸受体 (glycine receptor) 的内源性抑制性氨基酸。
      IC50和靶点:
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    • Kragler, A., Höfner, G., and Wanner, K.T.Novel parent structures for inhibitors of the murine GABA transporters mGAT3 and mGAT4Eur. J. Pharmacol.519(1-2),43-47(2005)

      Borden, L.A., Smith, K.E., Gustafson, E.L., et al.Cloning and expression of a betaine/GABA transporter from human brainJ. Neurochem.64(3),977-984(1995)

      Ramanathan, V.K., Brett, C.M., and Giacomini, K.M.Na+-dependent γ-aminobutyric acid (GABA) transport in the choroid plexus of rabbitBiochim. Biophys. Acta1330(1),94-102(1997)

      Aruoma, O.I., Halliwell, B., Hoey, B.M., et al.The antioxidant action of taurine, hypotaurine and their metabolic precursorsBiochem. J.256(1),251-255(1988)

      Nishimura, T., Duereh, M., Sugita, Y., et al.Protective effect of hypotaurine against oxidative stress-induced cytotoxicity in rat placental trophoblastsPlacenta36(6),693-698(2015)

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