Palmitoylcarnitine chloride
Cat. No.：YN370118
CAS No. ：6865-14-1
| 产品名称: | Palmitoylcarnitine chloride |
| CAS No.: | 6865-14-1 |
| Chemical Name: | 3-carboxy-N,N,N-trimethyl-2-[(1-oxohexadecyl)oxy]-1-propanaminium, chloride |
| Synonyms: | |
| 分子量: | 436.07 |
| 分子式: | C₂₃H₄₆ClNO₄ |
| SMILES: | CCCCCCCCCCCCCCCC(OC(CC(O)=O)C[N+](C)(C)C)=O.[Cl-] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Palmitoylcarnitine chloride 是一种脂肪酸衍生的线粒体底物，通过影响促炎途径，Ca2+流入和 DHT 样作用，可选择性降低大肠和前列腺癌细胞的细胞存活率。 |
| IC50和靶点: | |
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Bezaire, V., Bruce, C.R., Heigenhauser, G.J.F., et al.Identification of fatty acid translocase on human skeletal muscle mitochondrial membranes: Essential role in fatty acid oxidationAm. J. Physiol. Endocrinol. Metab.290(3),E509-E515(2006)
El-Hayek, R., Valdivia, C., Valdivia, H.H., et al.Activation of the Ca2+ release channel of skeletal muscle sarcoplasmic reticulum by palmitoyl carnitineBiophys. J.65(2),779-789(1993)
Stapleton, S.R., Currie, K.P.M., Scott, R.H., et al.Palmitoyl-DL-carnitine has calcium-dependent effects on cultured neurones from rat dorsal root gangliaBr. J. Pharmacol.107,1192-1197(1992)
Muraki, K., and Imaizumi, Y.A novel action of palmitoyl-L-carnitine in human vascular endothelial cellsJ. Pharmacol. Sci.92,252-258(2003)
Duizer, E., van der Wulp, C., Versantvoort, C.H.M., et al.Absorption enhancement, structural changes in tight junctions and cytotoxicity caused by palmitoyl carnitine in Caco-2 and IEC-18 cellsJ. Pharmacol. Exp. Ther.287(1),395-402(1998)
Ma, L., Kuang, K., Smith, R.W., et al.Modulation of tight junction properties relevant to fluid transport across rabbit corneal endotheliumExp. Eye Res.84(4),790-798(2007)
