all-trans-4-Oxoretinoic acid
Cat. No.：YN370370
| 产品名称: | all-trans-4-Oxoretinoic acid |
| CAS No.: | 38030-57-8 |
| Chemical Name: | 4-Oxoretinoic Acid; 4-Ketoretinoic Acid; 4-Oxo-all-trans-retinoic acid; 4-Oxo-atRA; 4-Oxotretinoin; 4-keto-Retinoic Acid; Ro 11-4824; Ro 12-4824; all-trans-4-Oxoretinoic Acid; |
| Synonyms: | all-trans 4-Keto Retinoic Acid |
| 分子量: | 314.42 |
| 分子式: | C₂₀H₂₆O₃ |
| SMILES: | CC(/C=C/C=C(/C=C/C1=C(C(CCC(C)1C)=O)C)C)=C\C(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | all-trans-4-Oxoretinoic acid，是维生素A 的活性代谢物，可通过作用核维甲酸受体 (RARs) 来诱导基因转录。 |
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Idrest, N., Marill, J., Flexor, M.A., et al.Activation of retinoic acid receptor-dependent transcription by all-trans-retinoic acid metabolites and isomersJ. Biol. Chem.277(25),31491-31498(2002)
Marill, J., Cresteil, T., Lanotte, M., et al.Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolitesMol. Pharmacol.58(6),1341-1348(2000)
Thatcher, J.E., Buttrick, B., Shaffer, S.A., et al.Substrate specificity and ligand interactions of CYP26A1, the human liver retinoic acid hydroxylaseMol. Pharmacol.80(2),228-239(2011)
Baron, J.M., Heise, R., Blaner, W.S., et al.Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitroJ. Invest. Dermatol.125(1),143-153(2005)
Van heusden, J., Wouters, W., Ramaekers, F.C.S., et al.All-trans-retinoic acid metabolites significantly inhibit the proliferation of MCF-7 human breast cancer cells in vitroBr. J. Cancer77(1),26-32(1998)
Pípal, M., Novák, J., Rafajová, A., et al.Teratogenicity of retinoids detected in surface waters in zebrafish embryos and its predictability by in vitro assaysAquat. Toxicol.246,106151(2022)
