DL-Mevalonolactone
Cat. No.：YN370392
CAS No. ：674-26-0
| 产品名称: | DL-Mevalonolactone |
| CAS No.: | 674-26-0 |
| Chemical Name: | tetrahydro-4-hydroxy-4-methyl-2H-pyran-2-one |
| Synonyms: | (±)-Mevalonolactone; Mevalolactone |
| 分子量: | 130.14 |
| 分子式: | C₆H₁₀O₃ |
| SMILES: | O=C1CC(C)(O)CCO1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | DL-Mevalonolactone ((±) -Mevalonolactone; Mevalolactone) 是甲羟戊酸的 δ-lactone 形式，甲羟戊酸途径的一个前体。DL-Mevalonolactone (Mevalonolactone) 可以降低大脑中线粒体膜电位 (∆Ψm)，NAD (P) H 的含量和 Ca2+的保留能力, 而且还诱导线粒体肿胀。 |
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Domingos, S.R., Pérez, C., and Schnell, M.On the structural intricacies of a metabolic precursor: Direct spectroscopic detection of water-induced conformational reshaping of mevalonolactoneJ. Chem. Phys.147(12),124310(2017)
Cecatto, C., Amaral, A.U., da Silva, J.C., et al.Mevalonolactone disrupts mitochondrial functions and induces permeability transition pore opening in rat brain mitochondria: Implications for the pathogenesis of mevalonic aciduriaNeurochem. Int.108,133-145(2017)
Yaluri, N., Modi, S., and Kokkola, T.Simvastatin induces insulin resistance in L6 skeletal muscle myotubes by suppressing insulin signaling, GLUT4 expression and GSK-3β phosphorylationBiochem. Biophys. Res. Commun.480(20),194-200(2016)
