15-Deoxy-Δ-12,14-prostaglandin J2
Cat. No.：YN370421
CAS No. ：87893-55-8
| 产品名称: | 15-Deoxy-Δ-12,14-prostaglandin J2 |
| CAS No.: | 87893-55-8 |
| Chemical Name: | 11-oxo-prosta-5Z,9,12E,14Z-tetraen-1-oic acid |
| Synonyms: | 15d-PGJ2; 15-Deoxy-Δ12,14-PGJ2 |
| 分子量: | 316.43 |
| 分子式: | C₂₀H₂₈O₃ |
| SMILES: | CCCCC/C=C/C=C1[C@H](C=CC\1=O)C/C=C\CCCC(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) 是一种环戊烯酮前列腺素和 PGD2 的代谢产物。15-Deoxy-Δ-12,14-prostaglandin J2 是一种选择性的PPARγ(EC50为 2 µM) 和共价的PPARδ激动剂。15-Deoxy-Δ-12,14-prostaglandin J2 促进 C3H10T1/2 成纤维细胞向脂肪细胞的有效分化，EC50为 7 μM。 |
| IC50和靶点: | [{name:"PPARγ:2 μM (EC50)'}, 'PPARδ', 'Human Endogenous Metabolite'] |
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Kliewer, S.A., Lenhard, J.M., Willson, T.M., et al.A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiationCell83(5),813-819(1995)
Forman, B.M., Tontonoz, P., Chen, J., et al.15-Deoxy-Δ12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγCell83(5),803-812(1995)
