L-2-Hydroxyglutaric acid
Cat. No.：YN370618
CAS No. ：13095-48-2
| 产品名称: | L-2-Hydroxyglutaric acid |
| CAS No.: | 13095-48-2 |
| Chemical Name: | 2S-hydroxy-pentanedioic acid |
| Synonyms: | (S)-2-Hydroxyglutaric acid |
| 分子量: | 148.11 |
| 分子式: | C₅H₈O₅ |
| SMILES: | O=C(O)[C@@H](O)CCC(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | L-2-Hydroxyglutaric acid ((S)-2-Hydroxyglutaric acid) 是一种表观遗传修饰因子，可用于肾癌研究。L-2-Hydroxyglutaric acid 可抑制组蛋白去甲基化酶 (histone demethylases)，从而促进组蛋白甲基化。 |
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Rzem, R., Veiga-da-Cunha, M., Noël, G., et al.A gene encoding a putative FAD-dependent L-2-hydroxyglutarate dehydrogenase is mutated in L-2-hydroxyglutaric aciduriaProc. Natl. Acad. Sci. USA101(48),16849-16854(2004)
Struys, E.A., Verhoeven, N.M., Roos, B., et al.Disease-related metabolites in culture medium of fibroblasts from patients with D-2-hydroxyglutaric aciduria, L-2-hydroxyglutaric aciduria, and combined D/L-2-hydroxyglutaric aciduriaClin. Chem.49(7),1133-1138(2003)
Chowdhury, R., Yeoh, K.K., Tian, Y.M., et al.The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylasesEMBO Rep.12(5),463-469(2011)
Xu, W., Yang, H., Liu, Y., et al.Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenasesCancer Cell19(1),17-30(2011)
