8-Isoprostaglandin F2α
Cat. No.：YN370675
CAS No. ：27415-26-5
| 产品名称: | 8-Isoprostaglandin F2α |
| CAS No.: | 27415-26-5 |
| Chemical Name: | 9α,11α,15S-trihydroxy-(8β)-prosta-5Z,13E-dien-1-oic acid |
| Synonyms: | |
| 分子量: | 354.48 |
| 分子式: | C₂₀H₃₄O₅ |
| SMILES: | CCCCC[C@H](O)/C=C/[C@@H]1[C@@H]([C@@H](O)C[C@H]1O)C/C=C\CCCC(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 8-Isoprostaglandin F2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. 8-Isoprostaglandin F2α is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. |
| IC50和靶点: | |
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Morrow, J.D., Hill, K.E., Burk, R.F., et al.A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanismProc. Natl. Acad. Sci. USA87(23),9383-9387(1990)
Morrow, J.D., Harris, T.M., and Roberts, L.J., IINoncyclooxygenase oxidative formation of a series of novel prostaglandins: Analytical ramifications for measurement of eicosanoidsAnal. Biochem.184(1),1-10(1990)
Morrow, J.D., Minton, T.A., and Roberts, L.J., IIThe F2-isoprostane, 8-epi-prostaglandin F2α, a potent agonist of the vascular thromboxane/endoperoxide receptor, is a platelet thromboxane/endoperoxide receptor antagonistProstaglandins44(2),155-163(1992)
Kiriyama, M., Ushikubi, F., Kobayashi, T., et al.Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cellsBr. J. Pharmacol.122(2),217-224(1997)
