Cholestenone
Cat. No.：YN370734
| 产品名称: | Cholestenone |
| CAS No.: | 601-57-0 |
| Chemical Name: | cholest-4-en-3-one |
| Synonyms: | 胆甾烯酮; 4-Cholesten-3-one |
| 分子量: | 384.64 |
| 分子式: | C₂₇H₄₄O |
| SMILES: | CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cholestenone (4-Cholesten-3-one) 是胆固醇的中间氧化产物，主要在肝脏中代谢。Cholestenone 在膜中具有很高的流动性，会影响胆固醇的翻转和外排。Cholestenone 可能会导致细胞长期功能缺陷。 |
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Salen, G., Batta, A.K., Tint, G.S., et al.Inverse relationship between plasma cholestanol concentrations and bile acid synthesis in sitosterolemiaJ. Lipid Res.35(10),1878-1887(1994)
Chen, C.-L., Wu, D.-C., Liu, M.-Y., et al.Cholest-4-en-3-one attenuates TGF-β responsiveness by inducing TGF-β receptors degradation in Mv1Lu cells and colorectal adenocarcinoma cellsJ. Recept. Signal Transduct. Res.37(2),189-199(2017)
Steinberg, D., Fredrickson, D.S., and Avigan, J.Effects of Δ4-cholestenone in animals and in manProc. Soc. Exp. Biol. Med.97(4),784-790(1958)
Wu, K., Li, W., Song, J., et al.Production, purification, and identification of cholest-4-en-3-one produced by cholesterol oxidase from Rhodococcus sp. in aqueous/organic biphasic systemBiochem. Insights8(Suppl 1),1-8(2015)
