Simvastatin acid ammonium
Cat. No.：YN370884
CAS No. ：139893-43-9
| 产品名称: | Simvastatin acid ammonium |
| CAS No.: | 139893-43-9 |
| Chemical Name: | (βR,δR,1S,2S,6R,8S,8aR)-8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-1-naphthaleneheptanoic acid, monoammonium salt |
| Synonyms: | 辛伐他汀铵盐; Tenivastatin ammonium |
| 分子量: | 453.61 |
| 分子式: | C₂₅H₄₃NO₆ |
| SMILES: | O=C(C[C@@H](C[C@@H](CC[C@H]1[C@H](C=CC2=C[C@@H](C[C@@H]([C@]12[H])OC(C(C)(CC)C)=O)C)C)O)O)[O-].[NH4+] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Simvastatin ammonium 是一种 simvastatin lactone metabolism 由 CYP3A4/5 在肠壁和肝脏中介导形成的活性代谢产物 (pKa=5.5)。Simvastatin ammonium 可减少吲哚硫酸盐介导的活性氧种类，并调节被 OATP3A1 基因转染的心肌细胞和 HEK293 细胞中 OATP3A1 的表达。 |
| IC50和靶点: | |
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Corsini, A., Maggi, F.M., and Catapano, A.L.Pharmacology of competitive inhibitors of HMG-CoA reductasePharmacol. Res.31(1),9-27(1995)
Vickers, S., Duncan, C.A., Vyas, K.P., et al.In vitro and in vivo biotransformation of simvastatin, an inhibitor of HMG CoA reductaseDrug Metab. Dispos.18(4),476-483(1990)
