2-Methoxyestradiol
Cat. No.：YN370899
CAS No. ：362-07-2
| 产品名称: | 2-Methoxyestradiol |
| CAS No.: | 362-07-2 |
| Chemical Name: | 2-methoxy-estra-1,3,5(10)-triene-3,17β-diol |
| Synonyms: | 二甲氧基雌二醇; 2-ME2; NSC-659853 |
| 分子量: | 302.41 |
| 分子式: | C₁₉H₂₆O₃ |
| SMILES: | OC1=CC2=C([C@]3(CC[C@@]4([C@H](CC[C@]4([C@@]3(CC2)[H])[H])O)C)[H])C=C1OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 2-Methoxyestradiol (2-ME2)，具有口服活性的 17β-雌二醇 (E2) 的内源性代谢产物，是凋亡诱导剂和血管生成抑制剂，具有有效的抗肿瘤活性。2-Methoxyestradiol (2-ME2) 也可破坏微管的稳定。 |
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Zacharia, L.C., Piché, C.A., Fielding, R.M., et al.2-hydroxyestradiol is a prodrug of 2-methoxyestradiolJ. Pharmacol. Exp. Ther.309(3),1093-1097(2004)
Mooberry, S.L.New insights into 2-methoxyestradiol, a promising antiangiogenic and antitumor agentCurr. Opin. Oncol.15(6),425-430(2003)
Mooberry, S.L.Mechanism of action of 2-methoxyestradiol: New developmentsDrug Resist. Updat.6(6),355-361(2003)
Becker, C.M., Rohwer, N., Funakoshi, T., et al.2-methoxyestradiol inhibits hypoxia-inducible factor-1α and suppressess growth of lesions in a mouse model of endometriosisAm. J. Pathol.172(2),534-544(2008)
Kanasaki, K., Palmsten, K., Sugimoto, H., et al.Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsiaNature453,1117-1123(2008)
