Resolvin D1
Cat. No.：YN371023
CAS No. ：872993-05-0
| 产品名称: | Resolvin D1 |
| CAS No.: | 872993-05-0 |
| Chemical Name: | 7S,8R,17S-trihydroxy-4Z,9E,11E,13Z,15E,19Z-docosahexaenoic acid |
| Synonyms: | RvD1 |
| 分子量: | 376.49 |
| 分子式: | C₂₂H₃₂O₅ |
| SMILES: | CC/C=C\C[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](C/C=C\CCC(O)=O)O)O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Resolvin D1 (RvD1) 是炎症的一种内源性促分解介质，衍生自在急性炎症的缓解阶段的 omega-3二十二碳六烯酸。Resolvin D1 通过调节肌动蛋白聚合来阻止促炎性中性粒细胞迁移，减少巨噬细胞中 TNF-α 介导的炎症，并增强巨噬细胞对凋亡细胞的吞噬作用。 |
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Hong, S., Gronert, K., Devchand, P.R., et al.Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammationJ. Biol. Chem.278(17),14677-14687(2003)
Ariel, A., and Serhan, C.N.Resolvins and protectins in the termination program of acute inflammationTrends Immunol.28(4),176-183(2007)
Serhan, C.N., Hong, S., Gronert, K., et al.Resolvins: A family of bioactive products of ω-3 fatty acid transformation circuits by aspirin treatment that counter proinflammation signalsJ. Exp. Med.196(8),1025-1037(2002)
Sun, Y.P., Oh, S.F., Uddin, J., et al.Resolvin D1 and its aspirin-triggered 17R epimer stereochemical assignments, anti-inflammatory properties, and enzymatic inactivationJ. Biol. Chem.282(13),9323-9334(2007)
