L-Canaline
Cat. No.：YN371198
| 产品名称: | L-Canaline |
| CAS No.: | 496-93-5 |
| Chemical Name: | O-amino-L-homoserine |
| Synonyms: | |
| 分子量: | 134.13 |
| 分子式: | C₄H₁₀N₂O₃ |
| SMILES: | N[C@@H](CCON)C(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | L-Canaline 是存在于许多豆科植物中的一种非蛋白质氨基酸。L-Canaline 是 L-canavanine 及其精氨酸酶催化的毒性代谢产物。L-Canaline 是一种有效且不可逆的鸟氨酸氨基转移酶抑制剂。L-Canaline 抑制疟原虫恶性疟原虫的生长，IC50为 297 nM。L-Canaline 具有抗癌和抗增殖作用。 |
| IC50和靶点: | |
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Bolkenius, F.N., Knödgen, B., and Seiler, N.DL-Canaline and 5-fluoromethylornithine. Comparison of two inactivators of ornithine aminotransferaseBiochem. J.268,409-414(1990)
Heilbronn, J., Wilson, J., and Berger, B.J.Tyrosine aminotransferase catalyzes the final step of methionine recycling in Klebsiella pneumoniaeJ. Bacteriol.181(6),1739-1747(1999)
Worthen, D.R., Ratliff, D.K., Rosenthal, G.A., et al.Structure-activity studies of L-canaline-mediated inhibition of porcinealanine aminotransferaseChem. Res. Toxicol.9(8),1293-1297(1996)
Rosenthal, G.A.L-Canavanine Transport and Utilization in Developing Jack Bean, Canavalia ensiformis (L.) DC. [Leguminosae]Plant Physiol.69,1066-1069(1982)
Berger, B.J.Antimalarial activities of aminooxy compoundsAntimicrob. Agents Chemother.44(9),2540-2542(2000)
