Tetrahydrocortisol
Cat. No.：YN371209
CAS No. ：53-02-1
| 产品名称: | Tetrahydrocortisol |
| CAS No.: | 53-02-1 |
| Chemical Name: | (3α,5β,11β)-3,11,17,21-tetrahydroxy-pregnan-20-one |
| Synonyms: | |
| 分子量: | 366.49 |
| 分子式: | C₂₁H₃₄O₅ |
| SMILES: | C[C@@]12[C@](C(CO)=O)(O)CC[C@@]1([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])[C@@H](O)C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tetrahydrocortisol 是皮质醇的代谢产物。尿中 Tetrahydrocortisol/Tetrahydrocortisone 的比例随着 11β-羟类固醇脱氢酶 (11β-HSD) 活性的增加而降低。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Shackleton, C.H.L.Role of a disordered steroid metabolome in the elucidation of sterol and steroid biosynthesisLipids47(1),1-12(2012)
Schiffer, L., Barnard, L., Baranowski, E.S., et al.Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive reviewJ. Steroid Biochem. Mol. Biol.194,105439(2019)
Kosicka, K., Siemiątkowska, A., Pałka, D., et al.Detailed analysis of cortisol, cortisone and their tetrahydro- and allo-tetrahydrometabolites in human urine by LC-MS/MSJ. Pharm. Biomed. Anal.140,174-181(2017)
Baudrand, R., Campino, C., Carvajal, C.A., et al.Increased urinary glucocorticoid metabolites are associated with metabolic syndrome, hypoadiponectinemia, insulin resistance and β cell dysfunctionSteroids76(14),1575-1581(2011)
