6-Thioguanine
Cat. No.：YN371786
| 产品名称: | 6-Thioguanine |
| CAS No.: | 154-42-7 |
| Chemical Name: | 2-amino-1,9-dihydro-6H-purine-6-thione |
| Synonyms: | Thioguanine; 2-Amino-6-purinethiol |
| 分子量: | 167.19 |
| 分子式: | C₅H₅N₅S |
| SMILES: | SC1=NC(N)=NC2=C1N=CN2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) 是一种抗白血病和免疫抑制剂，为 SARS 和 MERS 冠状病毒木瓜样蛋白酶 (PLpros) 的抑制剂，同时可有效抑制USP2的活性，IC50值分别为 25 μM 和 40 μM。 |
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Bohon, J., and de los Santos, C.R.Effect of 6-thioguanine on the stability of duplex DNANucleic Acids Res.33(9),2880-2886(2005)
LePage, G.A.Incorporation of 6-thioguanine into nucleic acidsCancer Res.20,403-408(1960)
Wang, H., and Wang, Y.6-Thioguanine perturbs cytosine methylation at the CpG dinucleotide site by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivoBiochemistry48(10),2290-2299(2009)
Yuan, B., Zhang, J., Wang, H., et al.6-Thioguanine reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNMT1Cancer Res.71(5),1904-1911(2011)
Issaeva, N., Thomas, H.D., Djureinovic, T., et al.6-thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistanceCancer Res.70(15),6268-6276(2010)
