Retinoic acid
Cat. No.：YN372214
| 产品名称: | Retinoic acid |
| CAS No.: | 302-79-4 |
| Chemical Name: | (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid |
| Synonyms: | 维生素A酸; Vitamin A acid; all-trans |
| 分子量: | 300.44 |
| 分子式: | C₂₀H₂₈O₂ |
| SMILES: | CC1(C)C(/C=C/C(C)=C/C=C/C(C)=C/C(O)=O)=C(C)CCC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Retinoic acid 是维生素A的代谢产物，在细胞生长，分化和器官发生中起重要作用。 Retinoic acid是RAR核受体的天然激动剂，对RARα/β/γ的IC50为14 nM。 Retinoic acid与PPARβ/δ结合的Kd值为17 nM。Retinoic acid 可以通过激活视黄酸受体抑制转录因子 Nrf2。 |
| IC50和靶点: | [{name:"PPARβ/δ:17 nM (Kd)"},{name: "PPARα:103 nM (Kd)"},{name: "PPARγ:178 nM (Kd)'}, 'Human Endogenous Metabolite', {'PPARα:14 nM (IC50)"},{name: "PPARγ:14 nM (IC50)"},{name: "RARβ:14 nM (IC50)"}] |
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Idrest, N., Marill, J., Flexor, M.A., et al.Activation of retinoic acid receptor-dependent transcription by all-trans-retinoic acid metabolites and isomersJ. Biol. Chem.277(25),31491-31498(2002)
Verma, A.K., Slaga, T.J., Wertz, P.W., et al.Inhibition of skin tumor promotion by retinoic acid and its metabolite 5,6-epoxyretinoic acidCancer Res.40(7),2367-2371(1980)
Cai, S.Y., Mennone, A., Soroka, C.J., et al.All-trans-retinoic acid improves cholestasis in α-naphthylisothiocyanate-treated rats and Mdr2-/- miceJ. Pharmacol. Exp. Ther.349(1),94-98(2014)
Kim, S.C., Kim, C.K., Axe, D., et al.All-trans-retinoic acid ameliorates hepatic steatosis in mice by a novel transcriptional cascadeHepatology59(5),1750-1760(2014)
