5-Aminosalicylic Acid
Cat. No.：YN372252
| 产品名称: | 5-Aminosalicylic Acid |
| CAS No.: | 89-57-6 |
| Chemical Name: | 5-amino-2-hydroxy-benzoic acid |
| Synonyms: | 5-氨基水杨酸; Mesalamine; 5-ASA; Mesalazine |
| 分子量: | 153.14 |
| 分子式: | C₇H₇NO₃ |
| SMILES: | OC1=C(C(O)=O)C=C(N)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 5-Aminosalicylic acid (Mesalamine) 是一种特异性的PPARγ激动剂，还抑制 p21-激活激酶1 (PAK1) 和NF-κB。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Warner, T.D., Giuliano, F., Vojnovic, I., et al.Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysisProc. Natl. Acad. Sci. USA96(13),7563-7568(1999)
Nugent, S.G., Kumar, D., Rampton, D.S., et al.Intestinal luminal pH in inflammatory bowel disease: Possible determinants and implications for therapy with aminosalicylates and other drugsGut48(4),571-577(2001)
Beiranvand, M.A review of the biological and pharmacological activities of mesalazine or 5-aminosalicylic acid (5-ASA): An anti-ulcer and anti-oxidant drugInflammopharmacology29(5),1279-1290(2021)
Schmidt, C., Fels, T., Baumeister, B., et al.The effect of 5-aminosalicylate and para-aminosalicylate on the synthesis of prostaglandin E2 and leukotriene B4 in isolated colonic mucosal cellsCurr. Med. Res. Opin.13(7),417-425(1996)
