Isotretinoin
Cat. No.：YN372257
| 产品名称: | Isotretinoin |
| CAS No.: | 4759-48-2 |
| Chemical Name: | 13-cis-retinoic acid |
| Synonyms: | 异维甲酸; 13-cis-Retinoic acid |
| 分子量: | 300.44 |
| 分子式: | C₂₀H₂₈O₂ |
| SMILES: | CC1(C)C(/C=C/C(C)=C/C=C/C(C)=C\C(O)=O)=C(C)CCC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Isotretinoin(13-cis-Retinoic acid)可作用于重度粉刺，还可用于脑癌，胰腺癌等化疗。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Blaner, W.S.Cellular metabolism and actions of 13-cis-retinoic acidJ. Am. Acad. Dermatol.45(5),S129-S135(2001)
Giannini, F., Maestro, R., Vukosavljevic, T., et al.All-trans, 13-cis and 9-cis retinoic acids induce a fully reversible growth inhibition in HNSCC cell lines: Implications for in vivo retinoic acid useInt. J. Cancer.70(2),194-200(1997)
Zouboulis, C.C., Korge, B., Akamatsu, H., et al.Effects of 13-cis-retinoic acid, all-trans-retinoic acid, and acitretin on the proliferation, lipid synthesis and keratin expression of cultured human sebocytes in vitroJ. Invest. Dermatol.96(5),792-797(1991)
Adams, J., Kiss, E., Arroyo, A.B., et al.13-cis retinoic acid inhibits development and progression of chronic allograft nephropathyAm. J. Pathol.167(1),285-298(2005)
Sieving, P.A., Chaudhry, P., Kondo, M., et al.Inhibition of the visual cycle in vivo by 13-cis retinoic acid protects from light damage and provides a mechanism for night blindness in isotretinoin therapyProc. Natl. Acad. Sci. USA98(4),1835-1840(2001)
