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> 产品中心 > 抑制剂 & 激动剂 > Metabolic Enzyme/Protease > Endogenous Metabolite

Cyclopamine

Cat. No.:YN372424

  • CAS No. :4449-51-8

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    • 产品名称: Cyclopamine
      CAS No.: 4449-51-8
      Chemical Name: (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3',6',10,11b-tetramethyl-spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol
      Synonyms:环巴胺; 11-Deoxojervine
      分子量:411.62
      分子式:C₂₇H₄₁NO₂
      SMILES:CC1=C2[C@@]([C@@]3([H])[C@]([C@@]4(C(C[C@@H](O)CC4)=CC3)C)([H])C2)([H])CC[C@@]15[C@@H]([C@@]6([H])[C@](C[C@H](C)CN6)([H])O5)C
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
      Select Batch:
      Purity: 98%
    • 产品描述: Cyclopamine 是Hedgehog通路的拮抗剂,在细胞实验中的IC50为 46 nM。Cyclopamine 还是一种选择性的Smo抑制剂。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Incardona, J.P., Gaffield, W., Kapur, R.P., et al.The teratogenic Veratrum alkaloid cyclopamine inhibits Sonic hedgehog signal transductionDevelopment125(18),3553-3562(1998)

      Frank-Kamenetsky, M., Zhang, X.M., Bottega, S., et al.Small-molecule modulators of Hedgehog signaling: Identification and characterization of smoothened agonists and antagonistsJ. Biol.1(2),10(2002)

      Xu, F.G., Ma, Q.Y., and Wang, Z.Blockade of hedgehog signaling pathway as a therapeutic strategy for pancreatic cancerCancer Lett.283(2),119-124(2009)

      Heretsch, P., Tzagkaroulaki, L., and Giannis, A.Cyclopamine and hedgehog signaling: Chemistry, biology, medical perspectivesAgnew. Chem. Int. Ed. Engl.49(20),3418-3427(2010)

      Mahindroo, N., Punchihewa, C., and Fujii, N.Hedgehog-Gli signaling pathway inhibitors as anticancer agentsJ. Med. Chem.52(13),3829-3845(2009)

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