Dimethyl fumarate
Cat. No.：YN372429
| 产品名称: | Dimethyl fumarate |
| CAS No.: | 624-49-7 |
| Chemical Name: | 2E-butenedioic acid, 1,4-dimethyl ester |
| Synonyms: | 富马酸二甲酯; DMF |
| 分子量: | 144.13 |
| 分子式: | C₆H₈O₄ |
| SMILES: | O=C(OC)/C=C/C(OC)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Dimethyl fumarate 是一种Nrf2激活剂，能够诱导上调抗氧化基因的表达。 |
| IC50和靶点: | |
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Albrecht, P., Bouchachia, I., Goebels, N., et al.Effects of dimethyl fumarate on neuroprotection and immunomodulationJ. Neuroinflammation9,163(2012)
Ockenfels, H.M., Schultewolter, T., Ockenfels, G., et al.The antipsoriatic agent dimethylfumarate immunomodulates T-cell cytokine secretion and inhibits cytokines of the psoriatic cytokine networkBr. J. Dermatol.139(3),390-395(1998)
García-Caballero, M., Marí-Beffa, M., Medina, M.A., et al.Dimethylfumarate inhibits angiogenesis in vitro and in vivo: A possible role for its antipsoriatic effect?J. Invest. Dermatol.131(6),1347-1355(2011)
Kappos, L., Gold, R., Miller, D.H., et al.Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: A multicentre, randomised, double-blind, placebo-controlled phase IIb studyLancet.372(9648),1463-1472(2008)
