3-Methyladenine
Cat. No.：YN372534
CAS No. ：5142-23-4
| 产品名称: | 3-Methyladenine |
| CAS No.: | 5142-23-4 |
| Chemical Name: | 3-methyl-3H-purin-6-amine |
| Synonyms: | 3-甲基腺嘌呤; 3-MA |
| 分子量: | 149.15 |
| 分子式: | C₆H₇N₅ |
| SMILES: | NC1=C2N=CN=C2N(C)C=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 3-Methyladenine (3-MA) 是PI3K的抑制剂。它通过抑制class III PI3K广泛作为自噬 (autophagy) 的抑制剂使用。 |
| IC50和靶点: | [{name:"PtdIns3Kγ:60 μM (IC50, Cell Assay)"},{name: "Vps34:25 μM (IC50, Cell Assay)'}, 'Autophagy', 'Mitophagy', 'Human Endogenous Metabolite'] |
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| Solvent & Solubility: |
Backer, J.M.The regulation and function of class III PI3Ks: Novel roles for Vps34Biochem. J.410,1-17(2008)
Seglen, P.O., and Gordon, P.B.3-Methyladenine: Specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytesProc. Natl. Acad. Sci. USA79,1889-1892(1982)
Chang, Y.Y., Juhász, G., Goraksha-Hicks, P., et al.Nutrient-dependent regulation of autophagy through the target of rapamycin pathwayBiochem. Soc. Trans.37,232-236(2009)
Wu, Y.T., Tan, H.L., Shui, G., et al.Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinaseJ. Biol. Chem.285(14),10850-10861(2010)
Ito, S., Koshikawa, N., Mochizuki, S., et al.3-Methyladenine suppresses cell migration and invasion of HT1080 fibrosarcoma cells through inhibiting phosphoinositide 3-kinases independently of autophagy inhibitionInt. J. Oncol.31,261-268(2007)
