Chenodeoxycholic Acid
Cat. No.：YN372682
| 产品名称: | Chenodeoxycholic Acid |
| CAS No.: | 474-25-9 |
| Chemical Name: | (3α,5β,7α)-3,7-dihydroxy-cholan-24-oic acid |
| Synonyms: | 鹅去氧胆酸; CDCA |
| 分子量: | 392.57 |
| 分子式: | C₂₄H₄₀O₄ |
| SMILES: | O=C(O)CC[C@@H](C)[C@]1([H])[C@]2(C)[C@](CC1)([H])[C@]3([H])[C@H](O)C[C@@](C4)([H])[C@@](CC[C@H]4O)(C)[C@]([H])3CC2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Chenodeoxycholic Acid 是一种疏水初级胆汁酸，能够活化核受体FXR，该受体与胆固醇代谢有关。 |
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Fiorucci, S., and Distrutti, E.Chenodeoxycholic acid: An update on its therapeutic applicationsBile acids and their receptors. Handbook of experimental pharmacology256,265-282(2019)
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Urizar, N.L., Liverman, A.B., Dodds, D.T., et al.A natural product that lowers cholesterol as an antagonist ligand for FXRScience296(5573),1703-1706(2002)
Tan, K.P., Yang, M., and Ito, S.Activation of nuclear factor (erythroid-2 like) factor 2 by toxic bile acids provokes adaptive defense responses to enhance cell survival at the emergence of oxidative stressMol. Pharmacol.72(5),1380-1390(2007)
