5-Fluorouracil
Cat. No.：YN372699
| 产品名称: | 5-Fluorouracil |
| CAS No.: | 51-21-8 |
| Chemical Name: | 5-fluoro-2,4(1H,3H)-pyrimidinedione |
| Synonyms: | 5-氟脲嘧啶; 5-FU |
| 分子量: | 130.08 |
| 分子式: | C₄H₃FN₂O₂ |
| SMILES: | O=C(N1)NC=C(F)C1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 5-Fluorouracil (5-FU) 是一种尿嘧啶的类似物 (nucleoside antimetabolite/analog)，是一种有效的抗肿瘤药。5-Fluorouracil 通过抑制胸苷酸合成酶影响嘧啶的合成，从而耗尽细胞内dTTP 池。5-Fluorouracil 诱导细胞凋亡 (apoptosis)，可用作化学敏化剂。5-Fluorouracil 还可抑制HIV病毒。5-Fluorouracil (5-FU) 可破坏外泌体特异性的 rRNA。 |
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Longley, D.B., Harkin, D.P., and Johnston, P.G.5-fluorouracil: Mechanisms of action and clinical strategiesNat. Rev. Cancer3(5),330-338(2003)
Tamatani, T., Ferdous, T., Takamaru, N., et al.Antitumor efficacy of sequential treatment with docetaxel and 5-fluorouracil against human oral cancer cellsInt. J. Oncol.41(3),1148-1156(2012)
