Lithocholic acid
Cat. No.：YN372752
| 产品名称: | Lithocholic acid |
| CAS No.: | 434-13-9 |
| Chemical Name: | (3α,5β)-3-hydroxy-cholan-24-oic acid |
| Synonyms: | 石胆酸; 3α-Hydroxy-5β-cholanic acid |
| 分子量: | 376.57 |
| 分子式: | C₂₄H₄₀O₃ |
| SMILES: | C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(O)=O)([H])[C@@]3([H])[C@]([C@@]4([C@](C[C@H](O)CC4)([H])CC3)C)([H])CC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Lithocholic acid是有毒的次级胆汁酸，能促使肝内胆汁淤积，能促进肿瘤发生。 |
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Little, J.M., Zimniak, P., Shattuck, K.E., et al.Metabolism of lithocholic acid in the rat: Formation of lithocholic acid 3-O-glucuronide in vivoJ. Lipid. Res.31(4),615-622(1990)
Makishima, M., Lu, T.T., Xie, W., et al.Vitamin D receptor as an intestinal bile acid sensorScience296(5571),1313-1316(2002)
Kozoni, V., Tsioulias, G., Shiff, S., et al.The effect of lithocholic acid on proliferation and apoptosis during the early stages of colon carcinogenesis: Differential effect on apoptosis in the presence of a colon carcinogenCarcinogenesis21(5),999-1005(2000)
Staudinger, J.L., Goodwin, B., Jones, S.A., et al.The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicityProc. Natl. Acad. Sci. USA98(6),3369-3374(2000)
Tan, K.P., Yang, M., and Ito, S.Activation of nuclear factor (erythroid-2 like) factor 2 by toxic bile acids provokes adaptive defense responses to enhance cell survival at the emergence of oxidative stressMol. Pharmacol.72(5),1380-1390(2007)
