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Meglutol

Cat. No.:YN372891

  • CAS No. :503-49-1

    • 产品资料
    • 生物活性
    • 参考文献
    • 产品名称: Meglutol
      CAS No.: 503-49-1
      Chemical Name: 3-hydroxy-3-methyl-pentanedioic acid
      Synonyms:Dicrotalic acid; 3-Hydroxy-3-methylglutaric acid
      分子量:162.14
      分子式:C₆H₁₀O₅
      SMILES:O=C(O)CC(C)(O)CC(O)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Meglutol是一种抗血脂剂, 降低胆固醇, 甘油三酯, 及血清β-脂蛋白和磷脂, 并抑制羟甲基戊二酰辅酶A还原酶活性, 这是在胆固醇生物合成中的限速酶。
      IC50和靶点:
      In Vitro:
      In Vivo:
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    • Medina-Franco, J.L., López-Vallejo, F., Rodríguez-Morales, S., et al.Molecular docking of the highly hypolipidemic agent α-asarone with the catalytic portion of HMG-CoA reductaseBioorg. Med. Chem. Lett.15(4),989-994(2005)

      Beg, Z.H., and Siddiqi, M.Hypocholesterolemic effect of 3-hydroxy-3-methylglutaric acidExperientia23(5),380(1967)

      Lupien, P.J., Tremblay, M., and Beg, Z.H.3-Hydroxy-3-methylglutaric acid: Protective action in experimental atherosclerosis in rabbitsAtherosclerosis18(3),407-416(1973)

      da Rosa, M.S., da Rosa-Junior, N.T., Parmeggiani, B., et al.3-Hydroxy-3-methylglutaric acid impairs redox and energy homeostasis, mitochondrial dynamics, and endoplasmic reticulum-mitochondria crosstalk in rat brainNeurotox. Res.37(2),314-325(2020)

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