Costunolide
Cat. No.：YN373027
CAS No. ：553-21-9
| 产品名称: | Costunolide |
| CAS No.: | 553-21-9 |
| Chemical Name: | 3aS,4,5,8,9,11aR-hexahydro-6E,10E-dimethyl-3-methylene-cyclodeca[b]furan-2(3H)-one |
| Synonyms: | 木香烃内酯; (+) |
| 分子量: | 232.32 |
| 分子式: | C₁₅H₂₀O₂ |
| SMILES: | O=C(O[C@@]1([H])[C@@]2([H])CC/C(C)=C/CC/C(C)=C/1)C2=C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Costunolide ((+)-Costunolide; Costus lactone) 是一种具有生物活性的倍半萜内酯，它具有抗氧化、抗炎、抗过敏、骨重塑、神经保护、促进毛发生长、抗癌和抗糖尿病的特性。Costunolide 可诱导乳腺癌细胞周期阻滞和凋亡 (apoptosis)。 |
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Kanno, S.I., Kitajima, Y., Kakuta, M., et al.Costunolide-induced apoptosis is caused by receptor-mediated pathway and inhibition of telomerase activity in NALM-6 cellsBiol. Pharm. Bull.31(5),1024-1028(2008)
Liu, C.Y., Chang, H.S., Chen, I.S., et al.Costunolide causes mitotic arrest and enhances radiosensitivity in human hepatocellular carcinoma cellsRadiat. Oncol.6,56(2011)
Lohberger, B., Rinner, B., Stuendl, N., et al.Sesquiterpene lactones downregulate G2/M cell cycle regulator proteins and affect the invasive potential of human soft tissue sarcoma cellsPLoS One8(6),e66300(2013)
Kim, J.H., Yang, Y.I., Lee, K.T., et al.Costunolide induces apoptosis in human endometriotic cells through inhibition of the prosurvival Akt and nuclear factor kappa B signaling pathwayBiol. Pharm. Bull.34(4),580-585(2011)
Butturini, E., Cavalieri, E., Carcereri de Prati, A., et al.Two naturally occurring terpenes, dehydrocostuslactone and costunolide, decrease intracellular GSH content and inhibit STAT3 activationPLoS One6(5),e20174(2011)
