Sarsasapogenin
Cat. No.：YN373034
CAS No. ：126-19-2
| 产品名称: | Sarsasapogenin |
| CAS No.: | 126-19-2 |
| Chemical Name: | (3β,5β,25S)-spirostan-3-ol |
| Synonyms: | Parigenin; Sarsagenin |
| 分子量: | 416.64 |
| 分子式: | C₂₇H₄₄O₃ |
| SMILES: | C[C@@H]1[C@]2(OC[C@@H](C)CC2)O[C@@]3([H])C[C@@]4([H])[C@]5([H])CC[C@]6([H])C[C@@H](O)CC[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@]31[H] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sarsasapogenin 是从中草药知母中分离到的甾体皂苷元，具有抗糖尿病、抗氧化、抗癌、抗炎等多种功效。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Power, F.B., and Salway, A.H.XXV-Chemical examination of sarsaparilla rootJ. Chem. Soc.105,201-219(1914)
Yin, Y., Zhao, X.-C., Wang, S.-J., et al.Synthesis and biological evaluation of novel sarsasapogenin derivatives as potential anti-tumor agentsSteroids93,25-31(2015)
Shen, S., Zhang, Y., Zhang, R., et al.Sarsasapogenin induces apoptosis via the reactive oxygen species-mediated mitochondrial pathway and ER stress pathway in HeLa cellsBiochem. Biophys. Res. Commun.441(2),519-524(2013)
Lim, S.M., Jeong, J.J., Kang, G.D., et al.Timosaponin AIII and its metabolite sarsasapogenin ameliorate colitis in mice by inhibiting NF-κB and MAPK activation and restoring Th17/Treg cell balance.Int. Immunopharmacol.25(2),493-503(2015)
Wang, Z.-D., Yao, G.-D., Wang, W., et al.Synthesis and evaluation of 26-amino acid methyl ester substituted sarsasapogenin derivatives as neuroprotective agents for Alzheimer's diseaseSteroids125,93-106(2017)
Ren, L.-X., Luo, Y.-F., Li, X., et al.Antidepressant-like effects of sarsasapogenin from Anemarrhena asphodeloides BUNGE (Liliaceae)Biol. Pharm. Bull.29(11),2304-2306(2006)
Hu, Y., Xia, Z., Sun, Q., et al.A new approach to the pharmacological regulation of memory: Sarsasapogenin improves memory by elevating the low muscarinic acetylcholine receptor density in brains of memory-deficit rat modelsBrain Res.1060(1-2),26-39(2005)
