Betulin
Cat. No.：YN373038
| 产品名称: | Betulin |
| CAS No.: | 473-98-3 |
| Chemical Name: | (3β)-lup-20(29)-ene-3,28-diol |
| Synonyms: | 白桦脂醇; Trochol |
| 分子量: | 442.72 |
| 分子式: | C₃₀H₅₀O₂ |
| SMILES: | C=C(C)[C@@H]1CC[C@]2(CO)CC[C@@]3(C)[C@]4(C)CC[C@@]5([H])C(C)(C)[C@@H](O)CC[C@]5(C)[C@@]4([H])CC[C@]3([H])[C@]21[H] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Betulin是一种SREBP抑制剂，在K562细胞中的IC50值是14.5 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Sakai, J., Nohturfft, A., Goldstein, J.L., et al.Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studiesJ. Biol. Chem.273(10),5785-5793(1998)
Brown, M.S., and Goldstein, J.L.The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factorCell89(3),331-340(1997)
Smith, L.H., Petrie, M.S., Morrow, J.D., et al.The sterol response element binding protein regulates cyclooxygenase-2 gene expression in endothelial cellsJ. Lipid Res.46,862-871(2005)
Tang, J.J., Li, J.G., Qi, W., et al.Inhibition of SREBP by a small molecule, betulin, improves hyperlipidemia and insulin resistance and reduces atherosclerotic plaquesCell Metab.13(1),44-56(2011)
Mullauer, F.B., Kessler, J.H., and Medema, J.P.Betulin is a potent anti-tumor agent that is enhanced by cholesterolPLoS One4(4),(2009)
